Trending...
- Cpics - A New Streaming Platform Dedicated to South Asian Content Announce Upcoming 2022 Activities
- Legal Consultation App Lawmato Hires First General Counsel and Director of Operations
- Iconic M&M'S® Brand Announces Global Commitment to Creating A World Where Everyone Feels They Belong USA - English USA - English USA - English USA - English USA - English USA - English
MONMOUTH JUNCTION, N.J. - JerseyDesk -- Biotech Support Group reports on an article, describing the simplicity and efficiency of their lipid clearance sample preparation technology for studying malignant ascites in peritoneal metastases of epithelial ovarian cancer. The citation is:
Yang, X. U. A. N., et al. "SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells (https://assets.researchsquare.com/files/rs-1087...)." (2021).
Malignant ascites in peritoneal metastases is a lipid-enriched microenvironment and is frequently involved in the poor prognosis of epithelial ovarian cancer (EOC). However, the detailed mechanisms underlying ovarian cancer (OvCa) cells dictating their lipid metabolic activities in promoting tumor progression remain elusive.
For this, the BSG product Cleanascite™ was used as a lipid-cleared control in the investigation. The article states: "Compared with the negative controls (OCM pretreated with the lipid removal reagent, Cleanascite), OvCa cells cocultured in the lipid-enriched OCM showed an increase of 18% in membrane fluidity." The authors describe a disruption of the cellular redox balance and subsequent iron-mediated lipid peroxidation in ascites-derived OvCa cells. They conclude that combinational treatment with SCD1/FADS2 inhibitors and cisplatin synergistically repressed tumor cell dissemination, providing a promising chemotherapeutic strategy against EOC platinum resistance and peritoneal metastases.
More on Jersey Desk
"We have over twenty references showing that Cleanascite™ was used to help identify a characteristic feature of in vitro cell response. Unlike methods that use solvents, Cleanascite™ is an aqueous suspension product and so it is very compatible with cellular models of disease. This ultimately helps with investigations to determine whether or not lipids, or factors associated with lipids, impart phenotypic changes to cells." states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.
To download whitepaper entitled "Cleanascite™ - Lipid Removal and Cell Response Applications", visit:
https://www.biotechsupportgroup.com/v/vspfiles/templates/257/pdf/CleanasciteCellResponseReferenceApplications113021.pdf
For more information visit: Cleanascite™ Lipid Removal Reagent and Clarification, at
http://www.biotechsupportgroup.com/Cleanascite-Lipid-Removal-Reagent-p/x2555.htm
About Biotech Support Group LLC
Following a tiered business strategy, the company continues its growth in the consumable research products area supporting the rapidly expanding installation of LC-MS instrument and computational infrastructure. For this market, key products include:biotechsupportgroup AlbuVoid™ and AlbuSorb™ for albumin depletion, Cleanascite™ for lipid adsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NuGel™ for functional proteomics. From these innovations, the company has acquired knowledgebase and biomarker intellectual property assets that support discoveries of protein markers from blood, with special emphasis on early detection and personalized medical decisions for cancer patients. For more information, go to http://www.biotechsupportgroup.com.
More on Jersey Desk
For Business Development, contact: Matthew Kuruc 732-274-2866, mkuruc@biotechsupportgroup.com (mailto:sales@biotechsupportgroup.com)
Yang, X. U. A. N., et al. "SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells (https://assets.researchsquare.com/files/rs-1087...)." (2021).
Malignant ascites in peritoneal metastases is a lipid-enriched microenvironment and is frequently involved in the poor prognosis of epithelial ovarian cancer (EOC). However, the detailed mechanisms underlying ovarian cancer (OvCa) cells dictating their lipid metabolic activities in promoting tumor progression remain elusive.
For this, the BSG product Cleanascite™ was used as a lipid-cleared control in the investigation. The article states: "Compared with the negative controls (OCM pretreated with the lipid removal reagent, Cleanascite), OvCa cells cocultured in the lipid-enriched OCM showed an increase of 18% in membrane fluidity." The authors describe a disruption of the cellular redox balance and subsequent iron-mediated lipid peroxidation in ascites-derived OvCa cells. They conclude that combinational treatment with SCD1/FADS2 inhibitors and cisplatin synergistically repressed tumor cell dissemination, providing a promising chemotherapeutic strategy against EOC platinum resistance and peritoneal metastases.
More on Jersey Desk
- Texas Arena League (TAL) Excited to Add Military Arena Polo Tournaments to 2022 Roster of Events; Dates and Locations Released
- Morven Museum & Garden announces a temporary closure and Jan & Feb 2022 Events
- We are the go-to Marketing Consultant Team
- Trina Rockstarr "Diamond Princess" Apes into Metaverse with 456 Collectors Club
- ExecuSearch Holdings, LLC Data Breach Prompts Investigation into Possible Class Action Lawsuit
"We have over twenty references showing that Cleanascite™ was used to help identify a characteristic feature of in vitro cell response. Unlike methods that use solvents, Cleanascite™ is an aqueous suspension product and so it is very compatible with cellular models of disease. This ultimately helps with investigations to determine whether or not lipids, or factors associated with lipids, impart phenotypic changes to cells." states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.
To download whitepaper entitled "Cleanascite™ - Lipid Removal and Cell Response Applications", visit:
https://www.biotechsupportgroup.com/v/vspfiles/templates/257/pdf/CleanasciteCellResponseReferenceApplications113021.pdf
For more information visit: Cleanascite™ Lipid Removal Reagent and Clarification, at
http://www.biotechsupportgroup.com/Cleanascite-Lipid-Removal-Reagent-p/x2555.htm
About Biotech Support Group LLC
Following a tiered business strategy, the company continues its growth in the consumable research products area supporting the rapidly expanding installation of LC-MS instrument and computational infrastructure. For this market, key products include:biotechsupportgroup AlbuVoid™ and AlbuSorb™ for albumin depletion, Cleanascite™ for lipid adsorption, HemogloBind™ and HemoVoid™ for hemoglobin removal, and NuGel™ for functional proteomics. From these innovations, the company has acquired knowledgebase and biomarker intellectual property assets that support discoveries of protein markers from blood, with special emphasis on early detection and personalized medical decisions for cancer patients. For more information, go to http://www.biotechsupportgroup.com.
More on Jersey Desk
- #1 Sponsor of Commercial Real Estate Partnerships, FNRP, Closes On Prominent NH Center, Hooksett Village
- Strategic Benefits Advisors, Inc. Data Breach Triggers Investigation into Class Action Lawsuit
- Onlive Server Launched Canada VPS Hosting with Upto 48 CPU CORE and Cloud VPS Control Panel
- Catalent, Inc. Announces Second Quarter Fiscal Year 2022 Earnings Conference Webcast
- Palatin Announces Presentation at the 2022 Crohn's and Colitis Congress
For Business Development, contact: Matthew Kuruc 732-274-2866, mkuruc@biotechsupportgroup.com (mailto:sales@biotechsupportgroup.com)
Source: Biotech Support Group
0 Comments
Latest on Jersey Desk
- Frank Clyburn to Leave Merck
- Iconic M&M'S® Brand Announces Global Commitment to Creating A World Where Everyone Feels They Belong USA - English USA - English USA - English USA - English USA - English USA - English
- Former US Navy Pirate Hunter Justin Myers Announces New Speaking Program
- Arizona Pest Control Becomes First Pest Control Company In The World To Launch NFT Collection
- Suburban Propane Partners, L.P. to Hold Fiscal 2022 First Quarter Results Conference Call
- Las Vegas and Atlantic City Welcomes Kool & the Gang in February
- OGLife Multiverse Embraces a Staple of Internet Culture in its Partnership with YouMeme as the Metaverse of Memes
- How Keona The Founder Of The Feminine School Is Branding Female Personalities With Etiquettes Coaching Across the Globe for Over A Decade
- Southern Ocean Chamber reports 2021 was All About Outcomes
- Cpics - A New Streaming Platform Dedicated to South Asian Content Announce Upcoming 2022 Activities
- Deshawn White's New Hip Hop Single 'Burn' Is Favored By Inspirational Radio
- ELLKAY RELEASES UPGRADED PLATFORM FOR LABS OFFERING COVID TESTING TO EMPLOYERS
- Alliance Advisors Further Expands Proxy Solicitation Team with Appointment of New Senior Vice President and Banking Expert
- REALOGY TO RELEASE FULL YEAR 2021 FINANCIAL RESULTS AND HOST WEBCAST ON FEBRUARY 17, 2022
- NICE and Magnet Forensics Partner to Digitally Transform Police Case Building and Investigations
- FairySwap DEX Launches with Radical Community-Oriented Tokenomics
- Semperis Extends Active Directory Protection With Expansion Into Australia and New Zealand
- Covanta Announces Early Results of Tender Offer and Consent Solicitation for 6.000% Senior Notes due 2027
- QPharma introduces Ti CRM 2.0--a Pharma CRM built for speed
- Winners Announced for 2022 International Juried Exhibition at The Center for Contemporary Art